PelA deacetylase activity is required for Pel polysaccharide synthesis in 1 Pseudomonas aeruginosa 2
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چکیده
PelA deacetylase activity is required for Pel polysaccharide synthesis in 1 Pseudomonas aeruginosa 2 Kelly M. Colvin, Noor Alnabelseya, Perrin Baker, John C. Whitney, 3 P. Lynne Howell and Matthew R. Parsek 4 5 Department of Microbiology 6 University of Washington 7 1959 NE Pacific St 8 Box number 357242 9 Seattle, WA 98195 10 11 Program in Molecular Structure & Function 12 Hospital for Sick Children 13 555 University Ave 14 Toronto, Ontario MSG 1X8, Canada 15 16 Department of Biochemistry 17 University of Toronto 18 1 Kings College Circle 19 Toronto, ON, M5S 1A8 20 21 To whom correspondence should be addressed 22 E-mail: [email protected] and [email protected] 23 Ph: (206) 221-1781, Fax: (206) 543-8297 or Ph: (416) 813-5378, Fax: (416) 813-5379 24 25 Current address: Department of Microbiology and Immunology, Stanford University, 299 26 Campus Dr., Stanford, CA 94305 27 28 Running Title: Deacetylase activity is required for biofilm formation 29 Copyright © 2013, American Society for Microbiology. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.02150-12 JB Accepts, published online ahead of print on 15 March 2013
منابع مشابه
PelA deacetylase activity is required for Pel polysaccharide synthesis in Pseudomonas aeruginosa.
The Pel polysaccharide serves as an intercellular adhesin for the formation and maintenance of biofilms in the opportunistic pathogen Pseudomonas aeruginosa. Pel biosynthesis requires the products of a seven-gene operon, pelA-pelG, all of which are necessary for Pel-dependent biofilm formation and Pel-related phenotypes. One of the genes, pelA, encodes a protein with a predicted polysaccharide ...
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